Mrs. Emily Shapiro is a neighbor (soon no longer to be) of Little Bill's. She only appeared in the episodes "The Campout" and "Same Sun, Same Moon, Same Stars." In the latter episode, she moves to Hawaii, but remains friends with Little Bill.
Her first name is currently unknown.
In "The Campout," she was voiced by the late Madeline Kahn in whose memory the episode was dedicated before the bedtime summary, but she was voiced by Kathy Najimy in "Same Moon, Same Sun, Same Star in which she moves even though she moved in this episode she makes a cameo in I got a letter in hawaii in little bill's fantasy delivering mail in an airplane yet she had already moved out and been replaced by Mr. Rojas in "The New Neighbors" which had aired two segments before her last appearance.